バイオ研究、臨床研究、治験、食薬品の開発、大阪大学発バイオベンチャー
Company
blackjack
経営理念
エビデンスにより食薬品、
医療機器・器材の
パラダイムシフト(paradigm shift)を創る
事業内容

エバンスでは、バイオインフォマティクス研究を通し疾病の機能解明や生命システムの理解を深め、 食薬品、医療機器・器材企業との新規食薬品、医療機器・器材の共同開発や治験、臨床試験を実施しています。

1.大学医師や研究者、地域機関病院医師、地域診療所医師とのネットワー クを基盤とした最新の医学情報と臨床移行研究(健康食品、特定保健用食品を含む)。

2.医系、文系の大学教官及び准教官者を中心としたネットワークによる適切な指針。

3.大学の研究成果や技術などを活用した低コスト研究開発。
論文実績

1) Kondo M, Nagano H, Wada H, Damdinsuren B, Yamamoto H, Hiraoka N, Eguchi H, Miyamoto A, Yamamoto T, Ota H, Nakamura M, Marubashi S, Dono K, Umeshita K, Nakamori S, Sakon M, Monden M. Combination of IFN-alpha and 5-fluorouracil induces apoptosis through IFN-alpha/beta receptor in human hepatocellular carcinoma cells. Clin Cancer Res. 2005 Feb 1;11(3):1277-86.
2) Yamamoto H, Kondo M(two first), Nakamori S, Nagano H, Wakasa K, Sugita Y, Chang-De J, Kobayashi S, Damdinsuren B, Dono K, Umeshita K, Sekimoto M, Sakon M, Matsuura N, Monden M. JTE-522, a cyclooxygenase-2 inhibitor, is an effective chemopreventive agent against rat experimental liver fibrosis1. Gastroenterology. 2003 Aug;125(2):556-71.
3) Kondo M, Nagano H, Sakon M, Hayashi S, Okami J, Dono K, Umeshita K, Nakamori S, Wakasa K, Monden M. The effect of beta-blocker on intractable ascites in cirrhotic patients undergoing hepatectomy for hepatocellular carcinoma. Hepatogastroenterology. 2003 Mar-Apr;50(50):504-6.
4) Kondo M, Dono K, Sakon M, Shimizu J, Nagano H, Nakamori S, Umeshita K, Wakasa K, Monden M. Adenosquamous carcinoma of the gallbladder. Hepatogastroenterology. 2002 Sep-Oct;49(47):1230-4.
5) Kondo M, Nagano H, Sakon M, Yamamoto H, Morimoto O, Arai I, Miyamoto A, Eguchi H, Dono K, Nakamori S, Umeshita K, Wakasa K, Ohmoto Y, Monden M. Expression of interferon alpha/beta receptor in human hepatocellular carcinoma. Int J Oncol. 2000 Jul;17(1):83-8.
6) Kondo M, Yamamoto H, Nagano H, Okami J, Ito Y, Shimizu J, Eguchi H, Miyamoto A, Dono K, Umeshita K, Matsuura N, Wakasa K, Nakamori S, Sakon M, Monden M. Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma. Clin Cancer Res. 1999 Dec;5(12):4005-12.
7)Ota H, Nagano H, Doki Y, Sekimoto M, Kondo M, et al. Expression of type I interferon receptor as a predictor of clinical response to interferon-alpha therapy of gastrointestinal cancers. : Oncol Rep. 2006 Aug;16(2):249-55.
8) Wada H, Nagano H, Yamamoto HYang Y, Kondo M, et al. Expression pattern of angiogenic factors and prognosis after hepatic resection in hepatocellular carcinoma: importance of angiopoietin-2 and hypoxia-induced factor-1 alpha. Liver Int. 2006 May;26(4):414-23.
9) Tang D, Nagano H, Yamamoto H, Wada H, Nakamura M, Kondo M, et al. Angiogenesis in cholangiocellular carcinoma: expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significance. Oncol Rep. 2006 Mar;15(3):525-32.
10) Damdinsuren B, Nagano H, Kondo M, et al. TGF-beta1-induced cell growth arrest and partial differentiation is related to the suppression of Id1 in human hepatoma cells. Oncol Rep. 2006 Feb;15(2):401-8.
11) Morimoto O, Nagano H, Miyamoto A, Fujiwara Y, Kondo M et al. Association between recurrence of hepatocellular carcinoma and alpha-fetoprotein messenger RNA levels in peripheral blood. Surg Today. 2005;35(12):1033-41.
12) Ota H, Nagano H, Sakon M, Eguchi H, Kondo M, et al. Treatment of hepatocellular carcinoma with major portal vein thrombosis by combined therapy with subcutaneous interferon-alpha and intra-arterial 5-fluorouracil; role of type 1 interferon receptor expression.
Br J Cancer. 2005 Sep 5;93(5):557-64
13) Damdinsuren B, Nagano H, Kondo M, et al. Expression of Id proteins in human hepatocellular carcinoma: relevance to tumor dedifferentiation. Int J Oncol. 2005 Feb;26(2):319-27.
14) Yamamoto T, Nagano H, Sakon M, Wada H, Eguchi H, Kondo M, et al. Partial contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/TRAIL receptor pathway to antitumor effects of interferon-alpha/5-fluorouracil against Hepatocellular Carcinoma. Clin Cancer Res. 2004 Dec 1;10(23):7884-95.
15) Kondo M, Kim SJ, Fujiwara Y, Iinuma A, Koji K, Irie Y, Tazumi K, Noguchi S, Monden M. [Evaluation of ten intravenous catheters for operability and safety in the infusion room. Gan To Kagaku Ryoho. 2004 Nov;31(12):2005-8.
16) Nakamura M, Nagano H, Sakon M, Kondo M,et al. [A case of long-term survivor with multiple pulmonary metastases of HCC after hepatic resection. Gan To Kagaku Ryoho. 2004 Oct;31(11):1939-42.
17) Wada H, Nagano H, Dono K, Kondo M, et al. Successful treatment for advanced cholangiocellular carcinoma with intrahepatic metastasis and/or portal vein tumor thrombi by intraarterial chemotherapy combined with 5-fluorouracil, adriamycin and cisplatin (FAP)--two cases report. Gan To Kagaku Ryoho. 2004 Oct;31(11):1711-3.
18) Damdinsuren B, Nagano H, Sakon M, Kondo M, et al. Interferon-beta is more potent than interferon-alpha in inhibition of human hepatocellular carcinoma cell growth when used alone and in combination with anticancer drugs. Ann Surg Oncol. 2003 Dec;10(10):1184-90.
19) Morimoto O, Nagano H, Sakon M, Fujiwara Y, Yamada T, Nakagawa H, Miyamoto A, Kondo M,et al. Diagnosis of intrahepatic metastasis and multicentric carcinogenesis by microsatellite loss of heterozygosity in patients with multiple and recurrent hepatocellular carcinomas. J Hepatol. 2003 Aug;39(2):215-21.
20) Eguchi H, Nagano H, Sakon M, Miyamoto A, Kondo M, et al. A successful resection and long-term survival of a patient with intrahepatic recurrences of combined hepatocellular-cholangiocarcinoma: report of a case. Surg Today. 2002;32(8):742-6.
21) Morimoto O, Nagano H, Sakon M, Eguchi H, Miyamoto A, Kondo M,et al. Liver abscess formation after microwave coagulation therapy applied for hepatic metastases from surgically excised bile duct cancer: report of a case. Surg Today. 2002;32(5):454-7.
22) Hayashi N, Yamamoto H, Hiraoka N, Dono K, Ito Y, Okami J, Kondo M,et al. Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm. Hepatology. 2001 Oct;34(4 Pt 1):638-50.
23) Miyamoto A, Nagano H, Sakon M, Fujiwara Y, Sugita Y, Eguchi H, Kondo M, et al. Clinical application of quantitative analysis for detection of hematogenous spread of hepatocellular carcinoma by real-time PCR. Int J Oncol. 2001 Mar;18(3):527-32.
24) Miyamoto A, Fujiwara Y, Sakon M, Nagano H, Sugita Y, Kondo M, et al. Development of a multiple-marker RT-PCR assay for detection of micrometastases of hepatocellular carcinoma. Dig Dis Sci. 2000 Jul;45(7):1376-82.
25) Eguchi H, Nagano H, Yamamoto H, Miyamoto A, Kondo M,et al. Augmentation of antitumor activity of 5-fluorouracil by interferon alpha is associated with up-regulation of p27Kip1 in human hepatocellular carcinoma cells. Clin Cancer Res. 2000 Jul;6(7):2881-90. 
26) Shamma A, Yamamoto H, Doki Y, Okami J, Kondo M, et al. Up-regulation of cyclooxygenase-2 in squamous carcinogenesis of the esophagus. Clin Cancer Res. 2000 Apr;6(4):1229-38.
27) Sakon M, Nagano H, Shimizu J, Kondo M, et al. Hepatic resection of hepatocellular carcinomas based on tumor hemodynamics. J Surg Oncol. 2000 Mar;73(3):179-81. 
28) Okami J, Yamamoto H, Fujiwara Y, Tsujie M, Kondo M, et al. Overexpression of cyclooxygenase-2 in carcinoma of the pancreas. Clin Cancer Res. 1999 Aug;5(8):2018-24.
29)Damdinsuren B, Nagano H, Wada H, Kondo M, Stronger growth-inhibitory effect of interferon (IFN)-beta compared to IFN-alpha is mediated by IFN signaling pathway in hepatocellular carcinoma cells. Int J Oncol. 2007 Jan;30(1):201-8.
30)Yamamoto T, Nagano H, Imai Y, Fukuda K, Matsumoto H, Kondo M, Ota H, Nakamura M, Wada H, Noda T, Damdinsuren B, Dono K, Umeshita K, Nakamori S, Sakon M, Wakasa K, Monden M. Successful treatment of multiple hepatocellular carcinoma with tumor thrombi in the major portal branches by intraarterial 5-fluorouracil perfusion chemotherapy combined with subcutaneous interferon-alpha and hepatectomy.Int J Clin Oncol. 2007 Apr;12(2):150-4. Epub 2007 Apr 27.
31)Nagano H, Sakon M, Eguchi H, Kondo M, Yamamoto T, Ota H, Nakamura M, Wada H, Damdinsuren B, Marubashi S, Miyamoto A, Takeda Y, Dono K, Umeshit K, Nakamori S, Monden M. Hepatic resection followed by IFN-alpha and 5-FU for advanced hepatocellular carcinoma with tumor thrombus in the major portal branch.
Hepatogastroenterology. 2007 Jan-Feb;54(73):172-9.
32)Arai I, Nagano H, Kondo M, Yamamoto H, Hiraoka N, Sugita Y, Ota H, Yoshioka S, Nakamura M, Wada H, Damdinsuren B, Kato H, Marubashi S, Miyamoto A, Takeda Y, Dono K, Umeshita K, Nakamori S, Wakasa K, Sakon M, Monden M. Overexpression of MT3-MMP in hepatocellular carcinoma correlates with capsular invasion.
Hepatogastroenterology. 2007 Jan-Feb;54(73):167-71.


他:英和文多数(健康食品案件などを含む)

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